If you are running anything bigger than a 225, yes, they will rub.
If your rims are the wrong offset, yes, they will rub.
As long as you are running the proper size tire, 215 is what most of us run, and your offset is correct, 44 I believe, you'll be fine. You'll have some play on the offset, meaning it doesn't have to be exactly 44, but it should be in the ballpark.
A few people have tried 225's, and a few have had them rub.